ESAO CONGRESS 2026
Iasi, Romania
From Bench to Bedside and Back Again

    Organ cross talk has emerged as a central paradigm in understanding the systemic consequences of kidney dysfunction, particularly in the context of uremic toxicity. Chronic kidney disease (CKD) is no longer viewed as isolated kidney disorders but as condition that triggers complex, bidirectional interactions among multiple organ systems, including the peridontium, gut, immune system, liver, heart, vasculature, brain, and the bone. Accumulation of uremic toxins—biologically active compounds normally cleared by the kidneys—plays a pivotal role in mediating these interactions. These toxins, contribute to inflammation, oxidative stress, endothelial dysfunction, post-translational modifications and metabolic disturbances across distant organs.

Recent advances highlight the importance of the gut–kidney axis, where dysbiosis enhances toxin generation, further exacerbating systemic injury. Similarly, cardio-renal and neuro-renal syndromes underscore how kidney dysfunction accelerates cardiovascular disease and cognitive impairment. Understanding these interconnected pathways offers new opportunities for therapeutic intervention, including modulation of the microbiome, targeted toxin removal, and strategies to interrupt maladaptive signaling cascades.

This symposium aims to integrate current insights into the mechanisms of organ cross talk in uremia, emphasizing translational approaches that may improve outcomes in patients with kidney disease.

• Griet Glorieux
• Dimitrios Stamatialis